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Science 28 September 1979:
Vol. 205. no. 4413, pp. 1405 - 1407
DOI: 10.1126/science.38504
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Articles

Science, Vol 205, Issue 4413, 1405-1407
Copyright © 1979 by American Association for the Advancement of Science

articles

Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment

NC Bacopoulos, EG Spokes, ED Bird, and RH Roth

In the brains of deceased schizophrenics who underwent long-term treatment with antipsychotic drugs, the concentration of homovanillic acid (a dopamine metabolite) was significantly increased in the orbital frontal, cingulate, and temporal tip areas of the cortex, but not in the putamen or the nucleus accumbens. The concentration of homovanillic acid was normal in the brains of schizophrenics who were not treated with drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Increased Brain Dopamine and Dopamine Receptors in Schizophrenia.
A. V. P. Mackay, L. L. Iversen, M. Rossor, E. Spokes, E. Bird, A. Arregui, I. Creese, and S. H. Snyder (1982)
Arch Gen Psychiatry 39, 991-997
   Abstract »    PDF »
Mental symptoms in Huntington's disease and a possible primary aminergic neuron lesion.
J. Mann, M Stanley, S Gershon, and M Rossor (1980)
Science 210, 1369-1371
   Abstract »    PDF »


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