Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 September 1979:
Vol. 205. no. 4413, pp. 1393 - 1395
DOI: 10.1126/science.382360
Prev | Table of Contents | Next

Articles

Science, Vol 205, Issue 4413, 1393-1395
Copyright © 1979 by American Association for the Advancement of Science

articles

Somatostatin cell processes as pathways for paracrine secretion

LI Larsson, N Goltermann, L de Magistris, JF Rehfeld, and TW Schwartz

Somatostatin is produced by gastrointestinal endocrine cells that have long, nonluminal, cytoplasmic processes. Such processes terminate on other cell types, including gastrin-producing and hydrochloric acid-producing cells, whose functions are profoundly affected by somatostatin. The findings suggest that somatostatin cells control the functions of other cells through local release of the peptide by way of cytoplasmic processes. Also, certain other types of gastrointestinal endocrine cells have similar cytoplasmic prolongations, which may have analogous local (paracrine) regulatory functions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuronostatin Encoded by the Somatostatin Gene Regulates Neuronal, Cardiovascular, and Metabolic Functions.
W. K. Samson, J. V. Zhang, O. Avsian-Kretchmer, K. Cui, G. L. C. Yosten, C. Klein, R.-M. Lyu, Y. X. Wang, X. Q. Chen, J. Yang, et al. (2008)
J. Biol. Chem. 283, 31949-31959
   Abstract »    Full Text »    PDF »
Cellular detection of sst2A receptors in human gastrointestinal tissue.
M Gugger, B Waser, A Kappeler, A Schonbrunn, and J C Reubi (2004)
Gut 53, 1431-1436
   Abstract »    Full Text »    PDF »
Cell-specific Processing of Chromogranin A in Endocrine Cells of the Rat Stomach.
P. Norlén, W. J. Curry, M. Björkqvist, A. Maule, R. T. Cunningham, R. B. Hogg, P. Harriott, C. F. Johnston, J. C. Hutton, and R. Håkanson (2001)
J. Histochem. Cytochem. 49, 9-18
   Abstract »    Full Text »
Immunocytochemical Evidence Suggesting that Diamine Oxidase Catalyzes Biosynthesis of {gamma}-Aminobutyric Acid in Antropyloric Gastrin Cells.
J. Hardt, L.-I. Larsson, and D. M. Hougaard (2000)
J. Histochem. Cytochem. 48, 839-846
   Abstract »    Full Text »
Apoptosis in Rat Gastric Antrum: Evidence That Regulation by Food Intake Depends on Nitric Oxide Synthase.
B.-H. Cao, K. Mortensen, D. Tornehave, and L.-I. Larsson (2000)
J. Histochem. Cytochem. 48, 123-132
   Abstract »    Full Text »
The New Biology of Gastrointestinal Hormones.
J. F. REHFELD (1998)
Physiol Rev 78, 1087-1108
   Abstract »    Full Text »    PDF »
Active immunization against somatostatin alters regulation of gastrin in response to gastric acid secretagogues.
S. L. Westbrook, G. H. McDowell, K. J. Hardy, and A. Shulkes (1998)
Am J Physiol Gastrointest Liver Physiol 274, G751-G756
   Abstract »    Full Text »    PDF »
Somatostatin Inhibition of Acid and Histamine Release by Activation of Somatostatin Receptor Subtype 2 Receptors in Rats.
K. Aurang, J. Wang, and K. C. K. Lloyd (1997)
J. Pharmacol. Exp. Ther. 281, 245-252
   Abstract »    Full Text »
Somatostatin: occurrence in urinary bladder epithelium and renal tubules of the toad, Bufo marinus.
J. Bolaffi, S Reichlin, D. Goodman, and J. Forrest Jr (1980)
Science 210, 644-646
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)