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Science 28 September 1979:
Vol. 205. no. 4413, pp. 1379 - 1380
DOI: 10.1126/science.224462
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Articles

Science, Vol 205, Issue 4413, 1379-1378
Copyright © 1979 by American Association for the Advancement of Science

articles

Morphine-naloxone interactions: a role for nonspecific morphine excitatory effects in withdrawal

DR Stevens and WR Klemm

The opiate antagonist naloxone precipitates withdrawal when given either 15 minutes after or 1 minute before a single injection of morphine in drug-naive mice. We propose that withdrawal signs arise from a synergistic mixture of excitatory influences that are direct (agonistic action on nonspecific opiate receptors) and indirect (sensory and affective disorders, stress, hormonal and neurotransmitter dysfunction, and so forth). The predominant effects during precipitated withdrawal are assumed to be direct, whereas during abstinence in tolerant animals they are indirect.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Excitatory and inhibitory effects of opiates in the rat vas deferens: a dual mechanism of opiate action.
Y. Jacquet (1980)
Science 210, 95-97
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