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Science 21 September 1979:
Vol. 205. no. 4412, pp. 1299 - 1301
DOI: 10.1126/science.472749
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Articles

Science, Vol 205, Issue 4412, 1299-1301
Copyright © 1979 by American Association for the Advancement of Science

articles

Baroreceptor activation reduces reactivity to noxious stimulation: implications for hypertension

BR Dworkin, RJ Filewich, NE Miller, N Craigmyle, and TG Pickering

The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raised by an infusion of phenylephrine, rats showed less running to terminate or avoid noxious stimuli than during saline infusions. This effect was not seen in rats with denervated baroreceptors. The results suggest that a rise of blood pressure could have motivational consequences significant for human hypertension.


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