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Science 21 September 1979:
Vol. 205. no. 4412, pp. 1275 - 1277
DOI: 10.1126/science.224461
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Articles

Science, Vol 205, Issue 4412, 1275-1277
Copyright © 1979 by American Association for the Advancement of Science

articles

Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons

LP Renaud, HW Blume, QJ Pittman, Y Lamour, and AT Tan

The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides.
E. A. Nillni and K. A. Sevarino (1999)
Endocr. Rev. 20, 599-648
   Abstract »    Full Text »
Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents.
A. I. Faden, G. B. Fox, L. Fan, G. L. Araldi, L. Qiao, S. Wang, and A. P. Kozikowski (1999)
Am J Physiol Regulatory Integrative Comp Physiol 277, R1196-R1204
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)