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ArticlesCopyright © 1979 by American Association for the Advancement of Science
Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons
The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
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