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Science 21 September 1979:
Vol. 205. no. 4412, pp. 1220 - 1225
DOI: 10.1126/science.472738
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Articles

Science, Vol 205, Issue 4412, 1220-1225
Copyright © 1979 by American Association for the Advancement of Science

articles

Psychotropic drugs as behavioral teratogens

CV Vorhees, RL Brunner, and RE Butcher

Three psychotropic drugs were administered to pregnant rats and were then evaluated for their behavioral and reproductive effects in the offspring. Control rats received either saline or vitamin A. Prochlorperazine had the most disruptive effects on reproduction and growth, but had the least effect on behavior. Propoxyphene had no apparent effects on reproduction or growth, but produced a variety of behavioral changes. Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development. The data suggest that systematic tests of behavior add important information to evaluations of reproductive toxicity that cannot, at present, be obtained by other means.


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Chloramphenicol administration during brain development: impairment of avoidance learning in adulthood.
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Current Status of Marijuana Research: Symposium on Marijuana Held July 1978 in Reims, France.
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