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Science 14 September 1979:
Vol. 205. no. 4411, pp. 1142 - 1144
DOI: 10.1126/science.382358
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Articles

Science, Vol 205, Issue 4411, 1142-1144
Copyright © 1979 by American Association for the Advancement of Science

articles

Sporozoite-induced malaria: therapeutic effects of glycolipids in liposomes

CR Alving, I Schneider, GM Swartz Jr, and EA Steck

Liposomes containing neutral glycolipids with a terminal glucose or galactose, when injected intravenously, prevented the appearance of erythrocytic forms of malaria (Plasmodium berghei) in mice previously injected with sporozoites. Inhibitory glycolipids included glucosyl, galactosyl, or lactosyl ceramide. Inhibition was not observed with liposomes containing ceramide, phosphocholine ceramide, sulfogalactosyl ceramide (sulfatide), or ganglioside GM1. Liposomes containing glycolipids did not inhibit infection transmitted by injecting blood containing erythrocytic stages of malaria. These results may have therapeutic implications in the treatment of malaria. Analysis of the mechanism of interference with the life cycle of malaria by liposomal glycolipids may yield information about the interactions of parasites with cellular membranes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Liposomes: Applications in Medicine.
R. Banerjee (2001)
J Biomater Appl 16, 3-21
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