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Science 7 September 1979:
Vol. 205. no. 4410, pp. 1033 - 1035
DOI: 10.1126/science.224457
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Articles

Science, Vol 205, Issue 4410, 1033-1035
Copyright © 1979 by American Association for the Advancement of Science

articles

Specific nonopiate receptors for beta-endorphin

E Hazum, KJ Chang, and P Cuatrecasas

Iodinated beta H-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes. The binding is inhibited by low concentrations of beta-endorphin and its D-alanine derivative, but is not affected by opiate agonists and antagonists, or by enkephalin analogs, beta-lipotropin, adrenocorticotrophic hormone, or alpha-melanocyte-stimulating hormone; this suggests the existence of a specific, non-opiate binding site (receptor) for beta-endorphin. The carboxy-terminal region of beta-endorphin is essential for this binding activity, since alpha-endorphin is not active. beta-Endorphin may be a circulating hormone with peripheral physiological effects that are not primarily mediated through interactions with opiate or enkephalin receptors.


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beta -Endorphin and natural killer cell cytolytic activity during prolonged exercise. Is there a connection?.
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Am J Physiol Regulatory Integrative Comp Physiol 275, R1725-R1734
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Intangibles in Medicine: An Attempt at a Balancing Perspective.
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Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity.
Y Shavit, J. Lewis, G. Terman, R. Gale, and J. Liebeskind (1984)
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The thymus-adrenal connection: thymosin has corticotropin-releasing activity in primates.
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Coping and immunosuppression: inescapable but not escapable shock suppresses lymphocyte proliferation.
M. Laudenslager, S. Ryan, R. Drugan, R. Hyson, and S. Maier (1983)
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Electrical stimulation of the midbrain mediates metastatic tumor growth.
R. Simon, E. Lovett 3rd, D Tomaszek, and J Lundy (1980)
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