Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 September 1979:
Vol. 205. no. 4410, pp. 1010 - 1012
DOI: 10.1126/science.572989
Prev | Table of Contents | Next

Articles

Science, Vol 205, Issue 4410, 1010-1012
Copyright © 1979 by American Association for the Advancement of Science

articles

High concentrations of glutathione in glandular stomach: possible implications for carcinogenesis

SC Body, HA Sasame, and MR Body

In laboratory rodents, concentrations of reduced glutathione (GSH) are exceedingly high (up to 7 to 8 millimolar) in the glandular gastric tissue compared to concentrations in other portions of the gastrointestinal tract or to those of most other organs. Gastric GSH varies diurnally, with the highest levels occurring in the late afternoon or early evening. Starvation, treatment with diethyl maleate, or cold-restraint stress all caused marked decreases in stomach GSH, whereas treatment with cobaltous chloride caused an increase in the GSH concentrations. The physiological significance of the high gastric GSH is unknown, but because this endogenous compound may strongly modulate (decrease or increase) the macromolecular binding of certain chemicals capable of inducing stomach tumors, the possible role of glutathione in the pathogenesis of chemically induced gastric cancer should be considered.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diffusion of cytotoxic concentrations of nitric oxide generated luminally at the gastro-oesophageal junction of rats.
K Asanuma, K Iijima, H Sugata, S Ohara, T Shimosegawa, and T Yoshimura (2005)
Gut 54, 1072-1077
   Abstract »    Full Text »    PDF »
In vivo Detection of Gastric Cancer in Rats by Electron Paramagnetic Resonance Imaging.
T. Mikuni, G. He, S. Petryakov, M. M. Fallouh, Y. Deng, R. Ishihara, P. Kuppusamy, M. Tatsuta, and J. L. Zweier (2004)
Cancer Res. 64, 6495-6502
   Abstract »    Full Text »    PDF »
An ultradian clock shapes genome expression in yeast.
M. W. Young (2004)
PNAS 101, 1118-1119
   Full Text »    PDF »
17{beta}-Estradiol Modulates Gastroduodenal Preneoplastic Alterations in Rats Exposed to the Carcinogen N-Methyl-N'-Nitro-Nitrosoguanidine.
M. Campbell-Thompson, G. Y. Lauwers, K. K. Reyher, J. Cromwell, and K. T. Shiverick (1999)
Endocrinology 140, 4886-4894
   Abstract »    Full Text »
The Histopathological and Biochemical Response of the Stomach of Male F344/N Rats Following Two Weeks of Oral Dosing with Ethyl Acrylate.
C. B. Frederick, G. A. Hazelton, and J. D. Frantz (1990)
Toxicol Pathol 18, 247-256
   Abstract »    PDF »
Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in mice.
H. Calvin, C Medvedovsky, and B. Worgul (1986)
Science 233, 553-555
   Abstract »    PDF »
Sulfhydryl compounds may mediate gastric cytoprotection.
S Szabo, J. Trier, and P. Frankel (1981)
Science 214, 200-202
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)