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Science 7 September 1979:
Vol. 205. no. 4410, pp. 1003 - 1004
DOI: 10.1126/science.472718
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Articles

Science, Vol 205, Issue 4410, 1003-1004
Copyright © 1979 by American Association for the Advancement of Science

articles

Insulin receptor binding in obesity: a reassessment

RI Misbin, JP O'Leary, and A Pulkkinen

A defect in the binding of insulin to circulating monocytes occurs when obese patients are hospitalized and fed a liberal carbohydrate diet. Under ordinary circumstances, most obese patients have normal insulin binding despite very high concentrations of serum insulin. These results show that insulin does not necessarily regulate its own receptor in vivo--as it does in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Insulin Resistance in a Young Man With Cystic Fibrosis.
M. E. Geffner, B. M. Lippe, R. M. Itami, S. A. Kaplan, B. K. Gillard, S. R. Levin, and I. L. Taylor (1984)
Arch Pediatr Adolesc Med 138, 677-680
   Abstract »    PDF »
Insulin receptors in hepatocytes: postreceptor events mediate down regulation.
J. Caro and J. Amatruda (1980)
Science 210, 1029-1031
   Abstract »    PDF »
Principles of Membrane Receptor Physiology and Their Application to Clinical Medicine.
R. J. POLLET and G. S. LEVEY (1980)
Ann Intern Med 92, 663-680
   Abstract »    PDF »


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