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Science 31 August 1979:
Vol. 205. no. 4409, pp. 932 - 934
DOI: 10.1126/science.472716
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Articles

Science, Vol 205, Issue 4409, 932-934
Copyright © 1979 by American Association for the Advancement of Science

articles

Lithium transport across red cell membrane: a cell membrane abnormality in manic-depressive illness

E Dorus, GN Pandey, R Shaughnessy, M Gaviria, E Val, S Ericksen, and JM Davis

In the families of manic-depressive patients, relatives with a history of affective disorders had a significantly higher ratio of mean red cell lithium to plasma lithium in vitro than relatives with no such history. A genetically controlled abnormality in lithium-sodium transport, the mechanism that determines the lithium ratio, may play a role in the etiology of some forms of affective disorders.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)