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Science 31 August 1979:
Vol. 205. no. 4409, pp. 915 - 917
DOI: 10.1126/science.224454
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Articles

Science, Vol 205, Issue 4409, 915-917
Copyright © 1979 by American Association for the Advancement of Science

articles

Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus

RB Tenser, RL Miller, and F Rapp

The incidence of trigeminal ganglion infection after corneal inoculation of guinea pigs with thymidine kinase-negative mutants of herpes simplex virus was markedly reduced compared to infection after inoculation of thymidine kinase-positive virus. Thymidine kinase-negative herpes simplex virus replicated well in ocular tissues in which dividing or potentially dividing cells were present, but not in trigeminal ganglion infection of nondividing neurons. Thymidine kinase-positive virus, however, replicated well in ocular tissues as well as in trigeminal ganglion. These results suggest that thymidine kinase expression of herpes simplex virus may be important in infections of sensory ganglia.


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Role of the VP16-Binding Domain of vhs in Viral Growth, Host Shutoff Activity, and Pathogenesis.
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Failure of Thymidine Kinase-Negative Herpes Simplex Virus To Reactivate from Latency following Efficient Establishment.
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J. Virol. 78, 520-523
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Replication of Herpes Simplex Virus Type 1 within Trigeminal Ganglia Is Required for High Frequency but Not High Viral Genome Copy Number Latency.
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J. Virol. 74, 965-974
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Experimental therapy of human glioma by means of a genetically engineered virus mutant.
R. Martuza, A Malick, J. Markert, K. Ruffner, and D. Coen (1991)
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Progressive Esophagitis from Acyclovir-Resistant Herpes Simplex: Clinical Roles for DNA Polymerase Mutants and Viral Heterogeneity?.
S. L. Sacks, R. J. Wanklin, D. E. Reece, K. A. Hicks, K. L. Tyler, and D. M. Coen (1989)
Ann Intern Med 111, 893-899
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Drugs Five Years Later: Acyclovir.
D. I. DORSKY and C. S. CRUMPACKER (1987)
Ann Intern Med 107, 859-874
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Herpes Simplex Virus Infection: Biology, Treatment, and Prevention.
S. E. STRAUS, J. F. ROONEY, J. L. SEVER, M. SEIDLIN, S. NUSINOFF-LEHRMAN, and K. CREMER (1985)
Ann Intern Med 103, 404-419
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Acyclovir and Suppression of Frequently Recurring Herpetic Whitlow.
O. L. LASKIN (1985)
Ann Intern Med 102, 494-495
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Resistance of Herpes Simplex to Acyclovir.
H. H. BALFOUR JR. (1983)
Ann Intern Med 98, 404-406
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Acyclovir for Chronic Mucocutaneous Herpes Simplex Virus Infection in Immunosuppressed Patients.
S. E. STRAUS, H. A. SMITH, C. BRICKMAN, P. de MIRANDA, C. McLAREN, and R. E. KEENEY (1982)
Ann Intern Med 96, 270-277
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Acyclovir Reaches Clinical Trial.
A. M. LERNER (1982)
Ann Intern Med 96, 370-372
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