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Science 31 August 1979:
Vol. 205. no. 4409, pp. 910 - 913
DOI: 10.1126/science.112678
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Articles

Science, Vol 205, Issue 4409, 910-913
Copyright © 1979 by American Association for the Advancement of Science

articles

Temperature dependence of ADH-induced water flow and intramembranous particle aggregates in toad bladder

WA Kachadorian, J Muller, SW Rudich, and VA DiScala

Antidiuretic hormone (ADH)-induced luminal intramembranous particle aggregates and hormonally stimulated water flow in toad urinary bladder are reduced simultaneously with a reduction in temperature. When water movement is factored by the aggregation response, the apparent activation energy for this process decreases from 12.1 +/- 1.6 to 3.0 +/- 2.3 kilocalories per mole. The data are consistent with the view that the particle aggregates contain sites for transmembrane water movement and that these sites behave as pores.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)