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Science 24 August 1979:
Vol. 205. no. 4408, pp. 827 - 829
DOI: 10.1126/science.462194
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Articles

Science, Vol 205, Issue 4408, 827-829
Copyright © 1979 by American Association for the Advancement of Science

articles

alpha-Melanocyte-stimulating hormone: reduction in adult rat brain after monosodium glutamate treatment of neonates

RL Eskay, MJ Brownstein, and RT Long

Intraperitoneal injection of monosodium glutamate in neonatal rates resulted in a 90 percent loss of alpha-melanocyte-stimulating hormone in hypothalamic and extrahypothalamic areas of the brain, whereas the amount of hormone in the pituitary gland did not change. The dramatic reduction of alpha-melanocyte-stimulating hormone in the brain suggests that is primary source there is the neuronal perikarya of the arcuate nucleus.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)