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Science 24 August 1979:
Vol. 205. no. 4408, pp. 816 - 818
DOI: 10.1126/science.572583
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Articles

Science, Vol 205, Issue 4408, 816-818
Copyright © 1979 by American Association for the Advancement of Science

articles

5-Bromodeoxyuridine inhibits sequence changes within inverted repeat DNA during embryogenesis

DG Dickinson and RF Baker

Previous studies on the genome of Strongylocentrotus purpuratus sea urchin have shown that changes in the nucleotide sequence of inverted repeat sequences occur during embryogenesis. The present study indicates that these sequence changes fail to occur when the embryos are raised in the presence of 5-bromodeoxyuridine. This drug is an analog of thymidine, is incorporated into the DNA during embryogenesis, and inhibits cell differentiation in these embryos.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNA methylation and gene function.
A Razin and A. Riggs (1980)
Science 210, 604-610
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