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Science 24 August 1979:
Vol. 205. no. 4408, pp. 810 - 816
DOI: 10.1126/science.223244
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Articles

Science, Vol 205, Issue 4408, 810-816
Copyright © 1979 by American Association for the Advancement of Science

articles

Voltage-dependent calcium and potassium ion conductances: a contingency mechanism for an associative learning model

DL Alkon

Persistent light-induced depolarization results from Ca2+ influx across a photoreceptor membrane. The marked dependence on potential of this Ca2+ influx and a Ca+-dependent K+ efflux accounts for enhancement of the light-induced depolarization when light is paired with rotation. A positive feedback cycle between light-induced depolarization and synaptic depolarization due to stimulus pairing can explain long-lasting behavioral changes produced by associative training but not control paradigms. The sensitivity of this Ca2+ influx to intracellular levels of adenosine 3'-5'-monophosphate suggests biochemical steps for this model of associative learning.


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Expression of Different Types of Inward Rectifier Currents Confers Specificity of Light and Dark Responses in Type A and B Photoreceptors of Hermissenda.
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Isolation of a G protein that is modified by learning and reduces potassium currents in Hermissenda.
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A spatial-temporal model of cell activation.
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Calcium-mediated reduction of ionic currents: a biophysical memory trace.
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Ca2+-dependent protein kinase injection in a photoreceptor mimics biophysical effects of associative learning.
J Acosta-Urquidi, D. Alkon, and J. Neary (1984)
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Protein kinase injection reduces voltage-dependent potassium currents.
D. Alkon, J Acosta-Urquidi, J Olds, G Kuzma, and J. Neary (1983)
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Primary changes of membrane currents during retention of associative learning.
D. Alkon, I Lederhendler, and J. Shoukimas (1982)
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Neural organization predicts stimulus specificity for a retained associative behavioral change.
J Farley and D. Alkon (1980)
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Membrane depolarization accumulates during acquisition of an associative behavioral change.
D. Alkon (1980)
Science 210, 1375-1376
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Associative Behavioral Modification in Hermissenda: Cellular Correlates.
T. J. CROW and D. L. ALKON (1980)
Science 209, 412-414
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