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Science 17 August 1979:
Vol. 205. no. 4407, pp. 723 - 725
DOI: 10.1126/science.462184
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Articles

Science, Vol 205, Issue 4407, 723-725
Copyright © 1979 by American Association for the Advancement of Science

articles

Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat

WJ Schwartz, CB Smith, L Davidsen, H Savaki, L Sokoloff, M Mata, DJ Fink, and H Gainer

Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.


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