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Science 17 August 1979:
Vol. 205. no. 4407, pp. 662 - 668
DOI: 10.1126/science.462174
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Articles

Science, Vol 205, Issue 4407, 662-668
Copyright © 1979 by American Association for the Advancement of Science

articles

Dynamics of skeletal pattern formation in developing chick limb

SA Newman and HL Frisch

During development of the embryonic chick limb the skeletal pattern is laid out as cartilaginous primordia, which emerge in a proximodistal sequence over a period of 4 days. The differentiation of cartilage is preceded by changes in cellular contacts at specific locations in the precartilage mesenchyme. Under realistic assumptions, the biosynthesis and diffusion through the extracellular matrix of a cell surface protein, such as fibronectin, will lead to spatial patterns of this molecule that could be the basis of the emergent primordia. As cellular differentiation proceeds, the size of the mesenchymal diffusion chamber is reduced in descrete steps, leading to sequential reorganizations of the morphogen pattern. The successive patterns correspond to observed rows of skeletal elements, whose emergence, in theory and in practice, depends on the maintenance of a unique boundary condition at the limb bud apex.


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Mechanisms of pattern formation in development and evolution.
I. Salazar-Ciudad, J. Jernvall, and S. A. Newman (2003)
Development 130, 2027-2037
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Self-organization of periodic patterns by dissociated feather mesenchymal cells and the regulation of size, number and spacing of primordia.
T. Jiang, H. Jung, R. Widelitz, and C. Chuong (1999)
Development 126, 4997-5009
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Matrix-driven translocation of cells and nonliving particles.
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