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Science 3 August 1979:
Vol. 205. no. 4405, pp. 502 - 503
DOI: 10.1126/science.451615
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Articles

Science, Vol 205, Issue 4405, 502-503
Copyright © 1979 by American Association for the Advancement of Science

articles

Iodide-induced hypothyroidism: a potential hazard during perinatal life

T Theodoropoulos, LE Braverman, and AG Vagenakis

The administration of iodide to pregnant and nursing rats induces hypothyroidism in the term fetus and neonatal rat through age 10 days as indicated by an increase in the serum concentration of thyroid-stimulating hormone and a decrease in the serum of thyroxine and triiodothyronine. Thyroid function returned to normal from age 18 through 60 days in spite of continued iodide administration, strongly suggesting that resistance to the inhibitory effect of iodide on thyroid hormone synthesis is developed at approximately 18 days of age. This perinatal rat model can be used to study the mechanisms responsible for iodide-induced hypothyroidism and goiter in human newborns whose mothers received iodide-containing medications during pregnancy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neonatal Thyroid Function After Administration of IV Iodinated Contrast Agent to 21 Pregnant Patients.
T. D. Atwell, A. N. Lteif, D. L. Brown, M. McCann, J. E. Townsend, and A. J. LeRoy (2008)
Am. J. Roentgenol. 191, 268-271
   Abstract »    Full Text »    PDF »
Opposite Variations in Maternal and Neonatal Thyroid Function Induced by Iodine Supplementation during Pregnancy.
S. B. Nøhr and P. Laurberg (2000)
J. Clin. Endocrinol. Metab. 85, 623-627
   Abstract »    Full Text »
Iodine and hypothyroidism in neonates with congenital heart disease.
N Linder, B Sela, B German, N Davidovitch, J Kuint, J Hegesh, D Lubin, and J Sack (1997)
Arch. Dis. Child. Fetal Neonatal Ed. 77, 239F-240
   Abstract »    Full Text »
Topical Iodine and Neonatal Hypothyroidism.
C. M. Gordon, D. H. Rowitch, M. L. Mitchell, and I. S. Kohane (1995)
Arch Pediatr Adolesc Med 149, 1336-1339
   Abstract »    PDF »


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