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Science 27 July 1979:
Vol. 205. no. 4404, pp. 415 - 417
DOI: 10.1126/science.451610
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Articles

Science, Vol 205, Issue 4404, 415-417
Copyright © 1979 by American Association for the Advancement of Science

articles

Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons

W Zieglgansberger, ED French, GR Siggins, and FE Bloom

The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the gamma-aminobutyric acid antagonists bicuculline, or magnesium ion. The recurrent inhibition of these cells evoked by transcallosal stimulation of the contralateral hippocampus is blocked by enkephalin but only shortened by acetylcholine. The results suggest that the opioids excite pyramidal neurons indirectly by inhibition of neighboring inhibitory interneurons (probably containing gamma-aminobutyric acid). This mechanism may be pertinent to the electrographic signs of addictive drugs.


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