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Science 27 July 1979:
Vol. 205. no. 4404, pp. 404 - 407
DOI: 10.1126/science.377490
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Articles

Science, Vol 205, Issue 4404, 404-407
Copyright © 1979 by American Association for the Advancement of Science

articles

Permeability of the cell-to-cell membrane channels in mammalian cell juncton

J Flagg-Newton, I Simpson, and WR Loewenstein

The channels in the junctions of various mammalian cell types--primary cultures and lines--were probed with a series of linear fluorescent amino acid and peptide molecules of different size and charge. Permeability is limited by probe size and electronegativity, these two factors apparently being related reciprocally. In respect to both factors, mammalian junctional channels are more restrictive than insect channels; hence the mammalian channels are narrower, more polar, or both. The channels of the various mammalian cell types differed slightly from each other; in some types the serum of the culture medium affected the channel permeability.


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