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Science 27 July 1979:
Vol. 205. no. 4404, pp. 366 - 372
DOI: 10.1126/science.221983
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Articles

Science, Vol 205, Issue 4404, 366-372
Copyright © 1979 by American Association for the Advancement of Science

articles

Pituitary hormones in brain: where, how, and why?

DT Krieger and AS Liotta

Peptide and protein hormones usually considered as being of pituitary origin have been detected within the central nervous system by means of radioimmunoassay, bioassay, and immunocytochemical techniques. Intracerebral administration of some of these hormones or fragments thereof elicit behavioral responses, suggesting that they may have a physiological role similar to that described for other peptidergic neurotransmitter or neuromodulator substances. Evidence available for some of these hormones indicates that they are synthesized within the central nervous system and that their regulation may differ from that of their pituitary counterparts.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)