Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 July 1979:
Vol. 205. no. 4403, pp. 325 - 327
DOI: 10.1126/science.451608
Prev | Table of Contents

Articles

Science, Vol 205, Issue 4403, 325-327
Copyright © 1979 by American Association for the Advancement of Science

articles

Ketone bodies are selectively used by individual brain regions

RA Hawkins and JF Biebuyck

Close study of 3-hydroxybutyrate uptake by brain suggests that its metabolism is limited by permeability. Furthermore, the permeability characteristics vary from region to region; areas known to have no blood-brain barrier show the highest rate of utilization. The results imply that rather than substitute fuels, ketone bodies should be considered supplements which partially supply specific areas but are incapable of supporting the entire energy requirement of all brain regions.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute Hypoglycemia.
K. A. Page, A. Williamson, N. Yu, E. C. McNay, J. Dzuira, R. J. McCrimmon, and R. S. Sherwin (2009)
Diabetes 58, 1237-1244
   Abstract »    Full Text »    PDF »
Ketogenic Diet Reduces Cytochrome c Release and Cellular Apoptosis Following Traumatic Brain Injury in Juvenile Rats.
Z. G. Hu, H. D. Wang, W. Jin, and H. X. Yin (2009)
Ann. Clin. Lab. Sci. 39, 76-83
   Abstract »    Full Text »    PDF »
Monocarboxylate transporter expression in mouse brain.
E. M. Koehler-Stec, I. A. Simpson, S. J. Vannucci, K. T. Landschulz, and W. H. Landschulz (1998)
Am J Physiol Endocrinol Metab 275, E516-E524
   Abstract »    Full Text »    PDF »
Reduced Counterregulation during Hypoglycemia with Raised Circulating Nonglucose Lipid Substrates: Evidence for Regional Differences in Metabolic Capacity in the Human Brain?.
M. L. Evans, K. Matyka, J. Lomas, A. Pernet, I. C. P. Cranston, I. Macdonald, and S. A. Amiel (1998)
J. Clin. Endocrinol. Metab. 83, 2952-2959
   Abstract »    Full Text »
Unique Effects of Infectious or Inflammatory Stress on Fat Metabolism in Rats.
H. A. Neufeld, J. G. Pace, M. V. Kaminski JR., P. Sobocinski, and D. J. Crawford (1982)
JPEN J Parenter Enteral Nutr 6, 511-521
   Abstract »    PDF »
Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats.
J. Davis, D Wirtshafter, K. Asin, and D Brief (1981)
Science 212, 81-83
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)