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Science 20 July 1979:
Vol. 205. no. 4403, pp. 317 - 318
DOI: 10.1126/science.451606
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Articles

Science, Vol 205, Issue 4403, 317-318
Copyright © 1979 by American Association for the Advancement of Science

articles

Opiate antagonists: a role in the treatment of hypovolemic shock

AI Faden and JW Holaday

The opiate antagonist naloxone has been used to treat shock following acute blood loss in conscious rats. Naloxone treatment rapidly increased mean arterial pressure and pulse pressure in this new shock model. More importantly, these blood pressure changes were sustained and survival was significantly increased with maloxone as compared with placebo treatment. From these findings, it may be inferred that endorphins may play a role in the pathophysiology of hypovolemic shock. It is suggested that narcotic antagonists may prove to be of therapeutic value in the treatment of shock.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Blockade of Delta Opioid Receptors in the Ventrolateral Periaqueductal Gray Region Inhibits the Fall in Arterial Pressure Evoked by Hemorrhage.
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Activation of spinal opioid receptors contributes to hypotension after hemorrhage in conscious rats.
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Prevention of Septic Ventilatory Depression With Naloxone.
G. J.-H. Chuang, C.-X. Gao, D. S. Mulder, and R. C.-J. Chiu (1987)
Arch Surg 122, 940-945
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Neuropeptides and Central Nervous System Injury: Clinical Implications.
A. I. Faden (1986)
Arch Neurol 43, 501-504
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Opiate Antagonists and Thyrotropin-Releasing Hormone: I. Potential Role in the Treatment of Shock.
A. I. Faden (1984)
JAMA 252, 1177-1180
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Impulse activity differentially regulates [Leu]enkephalin and catecholamine characters in the adrenal medulla.
E. LaGamma, J. Adler, and I. Black (1984)
Science 224, 1102-1104
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Diagnostic Dosages of Protirelin (TRH) Elevate BP by Noncatecholamine Mechanisms.
G. P. Zaloga, B. Chernow, R. Zajtchuk, R. Chin, T. G. Rainey, and C. R. Lake (1984)
Arch Intern Med 144, 1149-1152
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Brain Peptides as Intercellular Messengers: Implications for Medicine.
M. R. Brown and L. A. Fisher (1984)
JAMA 251, 1310-1315
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Failure of Naloxone to Reverse Clonidine Toxic Effect.
W. Banner Jr, M. E. Lund, and L. Clawson (1983)
Arch Pediatr Adolesc Med 137, 1170-1171
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An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans.
J Grevel and W Sadee (1983)
Science 221, 1198-1201
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A Case of Episodic Flushing and Organic Psychosis: Reversal by Opiate Antagonists.
D. J. GOLDSTEIN and H. R. KEISER (1983)
Ann Intern Med 98, 30-34
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Hypotensive effect of fasting: possible involvement of the sympathetic nervous system and endogenous opiates.
D Einhorn, J. Young, and L Landberg (1982)
Science 217, 727-729
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Endorphins in Septic Shock: Hemodynamic and Endocrine Effects of an Opiate Receptor Antagonist and Agonist.
F. N. Gahhos, R. C. J. Chiu, E. J. Hinchey, and G. K. Richards (1982)
Arch Surg 117, 1053-1057
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Thyrotropin-releasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock.
J. Holaday, R. D'Amato, and A. Faden (1981)
Science 213, 216-218
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Opiate antagonist improves neurologic recovery after spinal injury.
A. Faden, T. Jacobs, and J. Holaday (1981)
Science 211, 493-494
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Aspects of the Management of Shock.
K. I. SHINE, M. KUHN, L. S. YOUNG, and J. H. TILLISCH (1980)
Ann Intern Med 93, 723-734
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Opioid and nonopioid mechanisms of stress analgesia.
J. Lewis, J. Cannon, and J. Liebeskind (1980)
Science 208, 623-625
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