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Science 13 July 1979:
Vol. 205. no. 4402, pp. 202 - 203
DOI: 10.1126/science.221980
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Articles

Science, Vol 205, Issue 4402, 202-203
Copyright © 1979 by American Association for the Advancement of Science

articles

Angiotensin convertase activities in human alveolar macrophages: effects of cigarette smoking and sarcoidosis

LM Hinman, C Stevens, RA Matthay, J Bernard, and L Gee

Angiotensin I convertase activity has been found in human alveolar macrophages from normal volunteers and patients with pulmonary sarcoidosis. This activity is higher in the alveolar macrophages from smokers than from nonsmokers, and is even more elevated in sarcoid patients. The activity can be detected with both angiotensin I and bradykinin analogs and appears to require protein synthesis, but the enzyme is not secreted by alveolar macrophages in culture.


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Evidence That Macrophages in Atherosclerotic Lesions Contain Angiotensin II.
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Circulation 98, 800-807
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Cellular Distribution of Angiotensin-Converting Enzyme After Myocardial Infarction.
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Serum Angiotensin-Converting Enzyme Level Is Elevated in Patients With Human Immunodeficiency Virus Infection.
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Arch Intern Med 152, 321-324
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Bronchoalveolar Lavage: Role in the Pathogenesis, Diagnosis, and Management of Interstitial Lung Disease.
R. P. DANIELE, J. A. ELIAS, P. E. EPSTEIN, and M. D. ROSSMAN (1985)
Ann Intern Med 102, 93-108
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Immunologic Abnormalities in Sarcoidosis.
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Ann Intern Med 92, 406-416
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