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Science 13 July 1979:
Vol. 205. no. 4402, pp. 195 - 196
DOI: 10.1126/science.451588
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Articles

Science, Vol 205, Issue 4402, 195-196
Copyright © 1979 by American Association for the Advancement of Science

articles

Hyperthermia and local anesthetics: potentiation of survival of tumor-bearing mice

MB Yatvin, KH Clifton, and WH Dennis

Lidocaine infusion of a CA755 mammary adenocarcinoma growing in the hind leg of BDF1 mice results in a significant increase in the animals' survival when combined with heating for 1 hour in a 43.5 degrees C water bath. This ability of local anesthetics to prolong survival following hyperthermia is consistent with the hypothesis that increases in membrane fluidity influence sensitivity to heat. In view of the extensive clinical experience with local anesthetics, the delay between clinical application and the observation that they potentiate the action of hyperthermia in animals may be reduced.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Enhancement of Hyperthermia-induced Apoptosis by Local Anesthetics on Human Histiocytic Lymphoma U937 Cells.
Y. Arai, T. Kondo, K. Tanabe, Q.-L. Zhao, F.-J. Li, R. Ogawa, M. Li, and M. Kasuya (2002)
J. Biol. Chem. 277, 18986-18993
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