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Science 29 June 1979:
Vol. 204. no. 4400, pp. 1427 - 1429
DOI: 10.1126/science.451573
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Articles

Science, Vol 204, Issue 4400, 1427-1429
Copyright © 1979 by American Association for the Advancement of Science

articles

Dynamic changes in circulating 1,25-dihydroxyvitamin D during reproduction in rats

JW Pike, JB Parker, MR Haussler, A Boass, and SV Toverud

The concentrations of 1,25-dihydroxyvitamin D [1,25-(OH)2D], calcium, and phosphorus were measured in the serum of rats during pregnancy and at various stages of lactation. The concentration of 1,25-(OH)2D hormone increased almost two-fold during pregnancy and the latter part of lactation, but decreased to control levels or very low values immediately after birth and weaning, respectively. Furthermore, the concentration of 1,25-(OH)2D was inversely correlated with the concentration of calcium, suggesting that circulating 1,25-(OH)2D fluctuates in concert with calcium demands during the reproductive cycle. Parathyroidectomy in lactating rats caused a 70 percent inhibition of the normally observed 1,25-(OH)2D increase, indicating that parathyroid hormone, in response to changes in serum calcium, is a primary modulator of 1,25-(OH)2D during lactation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reproductive Defects Are Corrected in Vitamin D-Deficient Female Rats Fed a High Calcium, Phosphorus and Lactose Diet.
L. E. Johnson and H. F. DeLuca (2002)
J. Nutr. 132, 2270-2273
   Abstract »    Full Text »    PDF »
Calcitonin is a major regulator for the expression of renal 25-hydroxyvitamin D3-1alpha -hydroxylase gene in normocalcemic rats.
T. Shinki, Y. Ueno, H. F. DeLuca, and T. Suda (1999)
PNAS 96, 8253-8258
   Abstract »    Full Text »    PDF »
Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation.
C. S. Kovacs and H. M. Kronenberg (1997)
Endocr. Rev. 18, 832-872
   Abstract »    Full Text »


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