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Science 15 June 1979:
Vol. 204. no. 4398, pp. 1223 - 1224
DOI: 10.1126/science.451568
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Articles

Science, Vol 204, Issue 4398, 1223-1224
Copyright © 1979 by American Association for the Advancement of Science

articles

C26 sterol in a human urine

N Ikekawa, Y Fujimoto, M Isiguro, S Suwa, Y Hirayama, and H Mizunuma

A new C26 sterol, 22-trans-27-norcholesta-5,22-dien-3 beta-ol, was found in the urine of a 6-year-old girl, with a clinical diagnosis of congenital adrenal hyperplasia of the salt losing type, accompanied by symptoms of mixed sex anatomy and skin pigmentation. The structure of the sterol was determined by comparison with the synthetic compound. The sterol was also detected in ther serum. This appears to be the first case in which a C26 sterol has occurred in mammalia.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)