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Science 15 June 1979:
Vol. 204. no. 4398, pp. 1205 - 1207
DOI: 10.1126/science.221977
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Articles

Science, Vol 204, Issue 4398, 1205-1207
Copyright © 1979 by American Association for the Advancement of Science

articles

Phospholipid methylation unmasks cryptic beta-adrenergic receptors in rat reticulocytes

WJ Strittmatter, F Hirata, and J Axelrod

The effect of phospholipid methylation on the number of beta-adrenergic receptor binding sites was examined in rat reticulocyte membranes. Stimulation of phosphatidylcholine synthesis by the introduction of the methyl donor S-adenosyl-L-methionine into reticulocyte ghosts increased the number of beta-adrenergic receptor sites. The appearance of beta-adrenergic binding sites was dependent on the formation of phosphatidylcholine by the enzyme that converts phosphatidyl-N-monomethylethanolamine from phosphatidylethanolamine. Both the synthesis of phosphatidylcholine and the unmasking of cryptic receptors were time and temperature dependent and did not occur in the presence of the methyl transferase inhibitor, S-adenosyl-L-homocysteine.


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