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Science 8 June 1979:
Vol. 204. no. 4397, pp. 1106 - 1109
DOI: 10.1126/science.451556
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Articles

Science, Vol 204, Issue 4397, 1106-1109
Copyright © 1979 by American Association for the Advancement of Science

articles

GABA receptor control of parasympathetic outflow to heart: characterization and brainstem localization

JA DiMicco, K Gale, B Hamilton, and RA Gillis

Blockade of gamma-aminobutyric acid (GABA) receptor function by direct microinjection of the GABA receptor antagonist bicuculline into the nucleus ambiguus of the brainstem produced a marked, dose-related depression of heart rate and blood pressure which was mediated by the vagus nerve. This effect was not obtained in other regions of the brainstem and was reversed by the GABA receptor agonist muscimol. These data indicate that the nucleus ambiguus may be the site of a GABA receptor-mediated inhibition of vagal outflow.


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Hindbrain GABA receptors influence parasympathetic outflow to the stomach.
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Evidence for L-glutamate as the neurotransmitter of baroreceptor afferent nerve fibers.
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