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Science 8 June 1979:
Vol. 204. no. 4397, pp. 1103 - 1106
DOI: 10.1126/science.451555
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Articles

Science, Vol 204, Issue 4397, 1103-1106
Copyright © 1979 by American Association for the Advancement of Science

articles

Experimental allergic neuritis induced by sensitization with galactocerebroside

T Saida, K Saida, SH Dorfman, DH Silberberg, AJ Sumner, MC Manning, RP Lisak, and MJ Brown

Thirteen of 31 rabbits immunized repeatedly with bovine brain galactocerebroside developed experimental allergic neuritis, manifested by flaccid paresis and hypesthesia of four limbs, 2 to 11 months after the initial inoculation. Electrophysiological studies revealed multifocal conduction block of peripheral nerves. Perivenular demyelinative lesions associated with phagocytic mononuclear cells occurred in spinal ganglia, roots, and less frequently in distal nerves.


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