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Science 8 June 1979:
Vol. 204. no. 4397, pp. 1087 - 1088
DOI: 10.1126/science.109919
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Articles

Science, Vol 204, Issue 4397, 1087-1088
Copyright © 1979 by American Association for the Advancement of Science

articles

Nuclear transcripts of mouse heavy chain immunoglobulin genes contain only the expressed class of C-region sequences

KB Marcu, U Schibler, and RP Perry

In plasmacytoma cells producing IgG, IgA, or IgM immunoglobulin heavy chains, the large precursors of the heavy chain messenger RNA's contain nucleotide sequences that specify only the expressed class of constant region. This indicates that the switch from one class of heavy chain to another during B cell ontogeny does not occur by altered processing of a complex gene transcript.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Studies on the Nature and Germ-line Stability of DNA Sequences Flanking the Mouse Immunoglobulin Heavy-chain Constant-region Genes.
K. B. Marcu, N. Arnheim, J. Banerji, N. A. Penncavage, P. Seperack, R. Lang, R. Miesfeld, L. Harris, and R. Greenberg (1981)
Cold Spring Harb Symp Quant Biol 45, 899-911
   Abstract »    PDF »
Mapping of heavy chain genes for mouse immunoglobulins M and D.
C. Liu, P. Tucker, J. Mushinski, and F. Blattner (1980)
Science 209, 1348-1353
   Abstract »    PDF »
J genes for heavy chain immunoglobulins of mouse.
N Newell, J. Richards, P. Tucker, and F. Blattner (1980)
Science 209, 1128-1132
   Abstract »    PDF »
Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells.
A. Kenter and B. Birshtein (1979)
Science 206, 1307-1309
   Abstract »    PDF »


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