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Science 25 May 1979:
Vol. 204. no. 4395, pp. 866 - 868
DOI: 10.1126/science.35829
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Articles

Science, Vol 204, Issue 4395, 866-868
Copyright © 1979 by American Association for the Advancement of Science

articles

beta1- and beta2-Adrenergic receptors in rat cerebral cortex are independently regulated

KP Minneman, MD Dibner, BB Wolfe, and PB Molinoff

Repeated administration of the tricyclic antidepressant desmethylimipramine to adult rats for 10 days caused a 40% decrease in the density of beta1-adrenergic receptors in the cerebral cortex but had no effect on the density of beta2-adrenergic receptors. Conversely, destruction of noradrenergic neurons by administration of 6-hydroxydopamine to neonatal rats caused a 64% increase in the density of beta1-adrenergic receptors in adult cerebral cortex with no change in the density of beta2-adrenergic receptors. These results suggest that the beta-adrenergic receptors in rat cortex involved in neuronal function are primarily of the beta1 subtype.


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