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Science 25 May 1979:
Vol. 204. no. 4395, pp. 855 - 858
DOI: 10.1126/science.441739
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Articles

Science, Vol 204, Issue 4395, 855-858
Copyright © 1979 by American Association for the Advancement of Science

articles

Periodicity of deoxyribonuclease I digestion of chromatin

A Prunell, RD Kornberg, L Lutter, A Klug, M Levitt, and FH Crick

Two methods have been used to measure the single-strand lengths of the DNA fragments produced by deoxyribonuclease I digestion of chromatin. The average lengths obtained are muliples of about 10.4 bases, significantly different from the value of 10 previously reported. This periodicity in fragment lengths is closely related to the periodicity of the DNA double helix in chromatin, but the two values need not be exactly the same.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
DNase I digestion reveals alternating asymmetrical protection of the nucleosome by the higher order chromatin structure.
D. Z. Staynov (2000)
Nucleic Acids Res. 28, 3092-3099
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Nucleosome Structural Transition during Chromatin Unfolding Is Caused by Conformational Changes in Nucleosomal DNA.
I. M. Gavin, S. I. Usachenko, and S. G. Bavykin (1998)
J. Biol. Chem. 273, 2429-2434
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Alterations in Nucleosome Core Structure in Linker Histone-depleted Chromatin.
S. I. Usachenko, I. M. Gavin, and S. G. Bavykin (1996)
J. Biol. Chem. 271, 3831-3836
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Telomeric DNA-protein interactions of Oxytricha macronuclear DNA..
C M Price and T R Cech (1987)
Genes & Dev. 1, 783-793
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Helical Periodicity of DNA On and Off the Nucleosome as Probed by Nucleases.
A. Klug, L.C. Lutter, and D. Rhodes (1983)
Cold Spring Harb Symp Quant Biol 47, 285-292
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