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Science 11 May 1979:
Vol. 204. no. 4393, pp. 626 - 629
DOI: 10.1126/science.432667
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Articles

Science, Vol 204, Issue 4393, 626-629
Copyright © 1979 by American Association for the Advancement of Science

articles

Local cerebral glucose metabolism during controlled hypoxemia in rats

WA Pulsinelli and TE Duffy

2-Deoxy-[14C]glucose metabolism was examined in brains of hypoxic, normotensive rats by autoradiography, which revealed alternating cortical columns of high and low metabolism. Activity in white matter was increased severalfold over that in adjacent gray matter. The columns were anatomically related to penetrating cortical arteries with areas between arteries demonstrating higher rates of metabolism. The results suggest the presence of interarterial tissue oxygen gradients that influence regional glucose metabolism. The relatively greater sensitivity of white matter metabolism to hypoxia may lead to an understanding of white matter damage in postanoxic leukoencephalopathy.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Acute Hypoxia, Diabetes, and Neuroimmune Dysregulation: Converging Mechanisms in the Brain.
D. R. Johnson, C. L. Sherry, J. M. York, and G. G. Freund (2008)
Neuroscientist 14, 235-239
   Abstract »    PDF »
A Translation of Otto Binswanger's Article, 'The Delineation of the Generalized Progressive Paralyses'.
J. P. Blass, S. Hoyer, and R. Nitsch (1991)
Arch Neurol 48, 961-972
   Abstract »    PDF »


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