Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 April 1979:
Vol. 204. no. 4391, pp. 432 - 434
DOI: 10.1126/science.312530
Prev | Table of Contents | Next

Articles

Science, Vol 204, Issue 4391, 432-434
Copyright © 1979 by American Association for the Advancement of Science

articles

Voltage dependence of junctional conductance in early amphibian embryos

DC Spray, AL Harris, and MV Bennett

Isolated pairs of blastomeres from early amphibian embryos (Ambystoma, Rana, Xenopus) are electrontonically coupled. Junctional conductance and permeability to the dye Lucifer Yellow are markeldy and reversibly decreased by moderate transjunctional polarization in either direction. The relationship between junctional conductance and transjunctional voltage is sufficiently steep that a physiological role in regulation of intercellular communication is plausible.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gap Junctions.
D. A. Goodenough and D. L. Paul (2009)
Cold Spring Harb Perspect Biol 1, a002576
   Abstract »    Full Text »    PDF »
In Situ Characterization of a Rectifying Electrical Junction.
L. Rela and L. Szczupak (2007)
J Neurophysiol 97, 1405-1412
   Abstract »    Full Text »    PDF »
Gap junction expression and cell proliferation in differentiating cultures of Cx43 KO mouse hepatocytes.
T. Kojima, A. Fort, M. Tao, M. Yamamoto, and D. C. Spray (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1004-G1013
   Abstract »    Full Text »    PDF »
Voltage dependence of macroscopic and unitary currents of gap junction channels formed by mouse connexin50 expressed in rat neuroblastoma cells.
M. Srinivas, M. Costa, Y. Gao, A. Fort, G. I Fishman, and D. C Spray (1999)
J. Physiol. 517, 673-689
   Abstract »    Full Text »    PDF »
Switched single-electrode voltage-clamp amplifiers allow precise measurement of gap junction conductance.
A. Muller, M. Lauven, R. Berkels, S. Dhein, H.-R. Polder, and W. Klaus (1999)
Am J Physiol Cell Physiol 276, C980-C987
   Abstract »    Full Text »    PDF »
Direct High Affinity Modulation of Connexin Channel Activity by Cyclic Nucleotides.
C. G. Bevans and A. L. Harris (1999)
J. Biol. Chem. 274, 3720-3725
   Abstract »    Full Text »    PDF »
Cloning and expression of a Xenopus embryonic gap junction protein.
L Ebihara, E. Beyer, K. Swenson, D. Paul, and D. Goodenough (1989)
Science 243, 1194-1195
   Abstract »    PDF »
Bidirectional transmission at the rectifying electrotonic synapse: a voltage-dependent process.
C Giaume and H Korn (1983)
Science 220, 84-87
   Abstract »    PDF »
Gap junctional conductance is a simple and sensitive function of intracellular pH.
D. Spray, A. Harris, and M. Bennett (1981)
Science 211, 712-715
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)