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Science 27 April 1979:
Vol. 204. no. 4391, pp. 411 - 413
DOI: 10.1126/science.441728
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Articles

Science, Vol 204, Issue 4391, 411-413
Copyright © 1979 by American Association for the Advancement of Science

articles

Distribution of nitrogen-13 from labeled nitrate (13No3-) in humans and rats

JP Witter, SJ Gatley, and E Balish

The body distribution of gavaged or intravenously administered nitrate labeled with nitrogen-13 was studied in humans and rats with the following results: (i) the labeled compound is not quickly absorbed from the stomach; (ii) the concentration of the label increases inside the lower intestinal tract (cercum and large intestine) when ingested or intravenously injected; and (iii) humans and rats have the capacity to store a portion of the label in their bodies. These observation indicate that depletion of body stores, the passage of nitrate down the gut, or the secretion of nitrate into the intestinal lumen may be a better explanation of the urinary, ileal, and fecal concentrations of nitrate and nitrite recently measured in humans that a bacterial nitrification reaction in the intestines, as suggested by Tannenbbaum et al.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Evaluation of nitrate synthesis by intestinal microorganisms in vivo.
J. Witter, S. Gatley, and E Balish (1981)
Science 213, 449-450
   Abstract »    PDF »
Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration.
N. Parks, K. Krohn, C. Mathis, J. Chasko, K. Geiger, M. Gregor, and N. Peek (1981)
Science 212, 58-60
   Abstract »    PDF »


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