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Science 20 April 1979:
Vol. 204. no. 4390, pp. 330 - 332
DOI: 10.1126/science.34879
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Articles

Science, Vol 204, Issue 4390, 330-332
Copyright © 1979 by American Association for the Advancement of Science

articles

beta-Adrenergic regulation of adenosine 3',5'-monophosphate concentration in brain microvessels

TJ Herbst, ME Raichle, and JA Ferrendelli

Norepinephrine increases the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in an incubated suspension of brain microvessels. This response can be matched by other drugs that stimulate the beta receptors, but the alpha-adrenergic agonist phenylephrine is without effect; beta-adrenergic blockade abolishes the response while alpha-adrenergic blockade produces no change. The data support the contention that cerebral capillary function is subject to adrenergic neural control.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neurotransmitter receptor binding in bovine cerebral microvessels.
S. Peroutka, M. Moskowitz, J. Reinhard Jr, and S. Snyder (1980)
Science 208, 610-612
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)