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Science 13 April 1979:
Vol. 204. no. 4389, pp. 188 - 191
DOI: 10.1126/science.432641
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Articles

Science, Vol 204, Issue 4389, 188-191
Copyright © 1979 by American Association for the Advancement of Science

articles

Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors

JN Weinstein, RL Magin, MB Yatvin, and DS Zaharko

Liposomes with phase transitions a few degrees above physiological temperature delivered more than four times as much methotrexate to murine tumors heated to 42 degrees C as to unheated control tumors. Most of the accumulated drug appeared to be intracellular and bound to dihydrofolate reductase, the enzyme blocked by methotrexate in its role as an antineoplastic agent.


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