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Science 13 April 1979:
Vol. 204. no. 4389, pp. 187 - 188
DOI: 10.1126/science.107585
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Articles

Science, Vol 204, Issue 4389, 187-188
Copyright © 1979 by American Association for the Advancement of Science

articles

Uncoupling agents distinguish between the effects of metabolic inhibitors and transport inhibitors

MW Weiner

In studies with toad bladders, the uncoupling agent 2,4-dinitrophenol (DNP) reversed the inhibition of CO2 production produced by direct inhibition of transport. In contrast, DNP did not reverse the inhibition of CO2 production brought about by metabolic inhibitors. Therefore, the response to DNP distinguished between inhibition of transport and metabolism; this approach may be useful for the investigation of factors that regulate active transport.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)