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Science 6 April 1979:
Vol. 204. no. 4388, pp. 73 - 74
DOI: 10.1126/science.432628
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Articles

Science, Vol 204, Issue 4388, 73-74
Copyright © 1979 by American Association for the Advancement of Science

articles

Vitamin D deficiency and reproduction in rats

BP Halloran and HF DeLuca

Female weanling rats from a colony maintained on a diet low in vitamin D were raised on a diet that was deficient in vitamin D but was otherwise adequate. Vitamin D deficiency was confirmed in the rats by hypocalcemia and the absence of vitamin D metabolites in blood. These females gave birth to litters that were slightly smaller than control litters from females maintained on a vitamin D-containing diet. The pups from the vitamin D-deficient mothers appeared normal throughout lactation, and at weaning had normal concentrations of calcium and phosphate in the plasma. These results indicate that vitamin D and its metabolites are not necessary for reproduction and fetal development in the rat.


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