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Science 6 April 1979:
Vol. 204. no. 4388, pp. 69 - 71
DOI: 10.1126/science.219475
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Articles

Science, Vol 204, Issue 4388, 69-71
Copyright © 1979 by American Association for the Advancement of Science

articles

Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5

CA Kozak and WP Rowe

By means of an approach that combined the techniques of somatic cell genetics and Mendelian breeding studies, the inducibility locus, designated Cv, for ecotropic murine leukemia virus in BALB/c mice, was mapped to chromosome 5, 23 units from the locus for phosphoglucomutase-1, with gene order Cv-Pgm-1-Gus. This low-efficiency inducibility locus is therefore not allelic with the chromosome 7 loci previously described for two other mouse strains with high virus inducibility. These studies provide further evidence that endogenous ecotropic viruses represent viral genomes inserted at different chromosomal sites in the various mouse strains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15.
C. Kozak, J. Sears, and M. Hoggan (1983)
Science 221, 867-869
   Abstract »    PDF »
Structure and Infectivity of Integrated Murine Leukemia Virus DNA.
D. R. Lowy, E. Rands, S. K. Chattopadhyay, and G. L. Hager (1980)
Cold Spring Harb Symp Quant Biol 44, 1143-1151
   Abstract »    PDF »
Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5.
J. Ihle, D. Joseph, and J. Domotor Jr (1979)
Science 204, 71-73
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)