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Science 6 April 1979:
Vol. 204. no. 4388, pp. 66 - 68
DOI: 10.1126/science.432627
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Articles

Science, Vol 204, Issue 4388, 66-68
Copyright © 1979 by American Association for the Advancement of Science

articles

Chemical evidence for production of hydroxyl radicals during microsomal electron transfer

G Cohen and AI Cederbaum

Rat liver microsomes generate methane from dimethyl sulfoxide and ethylene from either methional or 2-keto-4-thiomethylbutyric acid during electron transfer initiated by reduced nicotinamide-adenine dinucleotide phosphate (NADPH). Hydrocarbon gas production is suppressed by hydroxyl radical scavenging agents. Azide, an inhibitor of catalase, augments the production of hydrocarbon gases. These observations constitute chemical evidence for the generation of hydroxyl radicals by microsomes.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)