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Science 23 March 1979:
Vol. 203. no. 4386, pp. 1249 - 1251
DOI: 10.1126/science.570725
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Articles

Science, Vol 203, Issue 4386, 1249-1251
Copyright © 1979 by American Association for the Advancement of Science

articles

Modified bases characterized in intact DNA by mass-analyzed ion kinetic energy spectrometry

AE Schoen, RG Cooks, and JL Wiebers

Pyrolysis of DNA into a chemical ionization source yields protonated bases and other base-containing ions. Kinetic energy spectra allow the characterization of the bases 5-methylcytosine and 1-methyladenine from underivatized salmon sperm DNA. Isomeric bases are distinguishable with this technique.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)