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Science 16 March 1979:
Vol. 203. no. 4385, pp. 1120 - 1121
DOI: 10.1126/science.424740
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Articles

Science, Vol 203, Issue 4385, 1120-1121
Copyright © 1979 by American Association for the Advancement of Science

articles

Hybrid myelomas producing antibodies against a human neuroblastoma antigen present on fetal brain

RH Kennett and F Gilbert

Spleen cells from mice immunized with a cultured human neuroblastoma were hybridized with the mouse plasmacytoma P3X63Ag8. Hybrid myelomas were screened for production of antibodies that reacted with human neuroblastomas but not with cells from other tissues. One of these hybridoma antibodies reacted with an antigen present on the six human neuroblastomas tested, one of two retinoblastomas, a glioblastoma, and fetal brain, but did not react with other tumors or tissues including adult human brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neuroblastoma: Clinical Perspectives, Monoclonal Antibodies, and Retinoic Acid.
R. C. SEEGER, S. E. SIEGEL, and N. SIDELL (1982)
Ann Intern Med 97, 873-884
   Abstract »    PDF »
Tumor location detected with radioactively labeled monoclonal antibody and external scintigraphy.
B Ballou, G Levine, T. Hakala, and D Solter (1979)
Science 206, 844-847
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)