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Science 16 March 1979:
Vol. 203. no. 4385, pp. 1115 - 1117
DOI: 10.1126/science.424739
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Articles

Science, Vol 203, Issue 4385, 1115-1117
Copyright © 1979 by American Association for the Advancement of Science

articles

DNA repair and longevity assurance in Paramecium tetraurelia

J Smith-Sonneborn

At given doses and clonal ages, ultraviolet irradiation-induced DNA damage reduced clonal life-span, but when followed by photoreactivation, extension of clonal life-span was observed. If photoreactivation preceded the ultraviolet treatment, no significant beneficial effect was detected. Because studies of others have shown that photoreactivation repair monomerizes the ultraviolet-induced cyclobutane dimers in DNA, but does not affect the other photoproducts, these results indicate that DNA damage can influence the duration of clonal life-span unless that damage is repaired. Repeated treatment with ultraviolet and photoreactivation resulted in significant mean and maximal clonal life-span extension when compared with untreated controls, and it is assumed that the rejuvenation effect was due to the correction or prevention of some age damage.


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