Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 9 March 1979:
Vol. 203. no. 4384, pp. 971 - 979
DOI: 10.1126/science.218285
Prev | Table of Contents | Next

Articles

Science, Vol 203, Issue 4384, 971-979
Copyright © 1979 by American Association for the Advancement of Science

articles

Thyroid hormone action at the cellular level

JH Oppenheimer

A large body of circumstantial evidence suggests that the basic unit of thyroid hormone action is the triiodothyronine nuclear receptor complex. This complex stimulates the formation, directly or indirectly, of a diversity of messenger RNA (mRNA) sequences. A generalized increase in mRNA as well as a disproportionate increase in a limited number of RNA sequences have been demonstrated. Regulation of thyroid hormone effects may be carried out largely at a local cellular level. Highly selective alterations in sensitivity to the triiodothyronine nuclear receptor complex may occur at specific target genes. Metabolic factors and hormones participate in such regulation. In a given tissue, alterations in the total number of receptor sites has not been shown to be useful as an index of thyroid hormone response, and local modulation of the response to the triiodothyronine receptor complex by a variety of factors other than triiodothyronine may be carried out at a postreceptor level.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Regulation of Mammary Gland Sensitivity to Thyroid Hormones During the Transition from Pregnancy to Lactation.
A. V. Capuco, E. E. Connor, and D. L. Wood (2008)
Experimental Biology and Medicine 233, 1309-1314
   Abstract »    Full Text »    PDF »
Thyroid Hormones Induce Sumoylation of the Cold Shock Domain-Containing Protein PIPPin in Developing Rat Brain and in Cultured Neurons.
E. Bono, V. Compagno, P. Proia, L. Raimondi, G. Schiera, V. Favaloro, V. Campo, M. Donatelli, and I. D. Liegro (2007)
Endocrinology 148, 252-257
   Abstract »    Full Text »    PDF »
G protein modulates thyroid hormone-induced Na+ channel activation in ventricular myocytes.
L. Sen, Y. Sakaguchi, and G. Cui (2002)
Am J Physiol Heart Circ Physiol 283, H2119-H2129
   Abstract »    Full Text »    PDF »
Glutamic Acid Decarboxylase Antibody Positivity Is Associated with an Impaired Insulin Response to Glucose and Arginine in Nondiabetic Patients with Autoimmune Thyroiditis.
A. L. Lethagen, U.-B. Ericsson, B. Hallengren, L. Groop, and T. Tuomi (2002)
J. Clin. Endocrinol. Metab. 87, 1177-1183
   Abstract »    Full Text »    PDF »
Pre- and Postnatal Lung Development, Maturation, and Plasticity: Invited Review: Pulmonary alveoli: formation, the "call for oxygen," and other regulators.
D. Massaro and G. D. Massaro (2002)
Am J Physiol Lung Cell Mol Physiol 282, L345-L358
   Abstract »    Full Text »    PDF »
Biochemistry, Cellular and Molecular Biology, and Physiological Roles of the Iodothyronine Selenodeiodinases.
A. C. Bianco, D. Salvatore, B. Gereben, M. J. Berry, and P. R. Larsen (2002)
Endocr. Rev. 23, 38-89
   Abstract »    Full Text »    PDF »
Acquired von Willebrand Syndrome Type 1 in Hypothyroidism: Reversal After Treatment With Thyroxine.
J. J. Michiels, W. Schroyens, Z. Bememan, and M. van der Planken (2001)
Clinical and Applied Thrombosis/Hemostasis 7, 113-115
   Abstract »    PDF »
Subchronic Sodium Chlorate Exposure in Drinking Water Results in a Concentration-Dependent Increase in Rat Thyroid Follicular Cell Hyperplasia.
M. J. Hooth, A. B. Deangelo, M. H. George, E. T. Gaillard, G. S. Travlos, G. A. Boorman, and D. C. Wolf (2001)
Toxicol Pathol 29, 250-259
   Abstract »    PDF »
A 90-Day Drinking Water Toxicity Study in Rats of the Environmental Contaminant Ammonium Perchlorate.
J. C. Siglin, D. R. Mattie, D. E. Dodd, P. K. Hildebrandt, and W. H. Baker (2000)
Toxicol. Sci. 57, 61-74
   Abstract »    Full Text »    PDF »
Isometric force and endurance in soleus muscle of thyroid hormone receptor-alpha 1- or -beta -deficient mice.
C. Johansson, J. Lannergren, P.-K. Lunde, B. Vennstrom, P. Thoren, and H. Westerblad (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R598-R603
   Abstract »    Full Text »    PDF »
Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-beta or both alpha 1 and beta.
C. Johansson, S. Gothe, D. Forrest, B. Vennstrom, and P. Thoren (1999)
Am J Physiol Heart Circ Physiol 276, H2006-H2012
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Thyroid Hormone-stimulated Steroidogenesis in Mouse Leydig Tumor Cells. INVOLVEMENT OF THE STEROIDOGENIC ACUTE REGULATORY () PROTEIN.
P. R. Manna, M. Tena-Sempere, and I. T. Huhtaniemi (1999)
J. Biol. Chem. 274, 5909-5918
   Abstract »    Full Text »    PDF »
Thyroid Hormone Receptor Does Not Heterodimerize with the Vitamin D Receptor but Represses Vitamin D Receptor-Mediated Transactivation.
M. Raval-Pandya, L. P. Freedman, H. Li, and S. Christakos (1998)
Mol. Endocrinol. 12, 1367-1379
   Abstract »    Full Text »
Evidence that decreased heart rate in thyroid hormone receptor-alpha 1-deficient mice is an intrinsic defect.
C. Johansson, B. Vennstrom, and P. Thoren (1998)
Am J Physiol Regulatory Integrative Comp Physiol 275, R640-R646
   Abstract »    Full Text »    PDF »
THE DIRECT EFFECTS OF 3,5,3'-TRIIODO-L-THYRONINE (T3) ON MYOCYTE CONTRACTILE PROCESSES: Insights into mechanisms of action.
J. D. Walker, F. A. Crawford Jr., R. Mukherjee, and F. G. Spinale (1995)
J. Thorac. Cardiovasc. Surg. 110, 1369-1380
   Abstract »    Full Text »
PRETREATMENT WITH 3,5,3' TRIIODO-L-THYRONINE (T3): Effects on myocyte contractile function after hypothermic cardioplegic arrest and rewarming.
J. D. Walker, F. A. Crawford, and F. G. Spinale (1995)
J. Thorac. Cardiovasc. Surg. 110, 315-327
   Abstract »    Full Text »
Treatment With Thyroid Hormone-Reply.
D. S. Cooper (1989)
JAMA 262, 1774-1775
   Abstract »    PDF »
Regulation of Salivary Proteins.
D.A. Johnson, O.F. Alvares, K.R. Etzel, and D.N. Kalu (1987)
Journal of Dental Research 66, 576-582
   Abstract »    PDF »
Thyroid hormone induction of an autocrine growth factor secreted by pituitary tumor cells.
P. Hinkle and P. Kinsella (1986)
Science 234, 1549-1552
   Abstract »    PDF »
Thyroid Hormone Action at the Nuclear Level.
J. H. OPPENHEIMER (1985)
Ann Intern Med 102, 374-384
   Abstract »    PDF »
Thyroidectomy increases rat hepatic ferritin iron.
J. Winkelmann, C. Mariash, H. Towle, and J. Oppenheimer (1981)
Science 213, 569-571
   PDF »
Binding and mobility of the cell surface receptors for 3,3',5-triiodo-L-thyronine.
F. Maxfield, M. Willingham, I Pastan, P Dragsten, and S. Cheng (1981)
Science 211, 63-65
   Abstract »    PDF »
Thyroid hormone receptor-containing fragment released from chromatin by deoxyribonuclease I and micrococcal nuclease.
D. Jump and J. Oppenheimer (1980)
Science 209, 811-813
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)