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Science 9 March 1979:
Vol. 203. no. 4384, pp. 1019 - 1021
DOI: 10.1126/science.424726
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Articles
Science, Vol 203, Issue 4384, 1019-1021
Copyright © 1979 by American Association for the Advancement of Science
Methylation of mouse liver DNA studied by means of the restriction enzymes msp I and hpa II
J Singer,
J Roberts-Ems,
and
AD Riggs
The restriction enzymes Hpa II and Msp I both recognize the sequence 5'-CCGG (C, cytosine; G, guanine). However, Hpa II cuts mouse liver DNA to fragments four times larger than does Msp I. The size of DNA cut by Msp I is close to that predicted from base composition and nearest neighbor analysis. The most probable explanation of these results is that in mouse the site 5'-CCGG is highly methylated.
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