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Science 2 March 1979:
Vol. 203. no. 4383, pp. 883 - 887
DOI: 10.1126/science.217087
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Articles

Science, Vol 203, Issue 4383, 883-887
Copyright © 1979 by American Association for the Advancement of Science

articles

Molecular cloning of polyoma virus DNA in Escherichia coli: plasmid vector system

MA Israel, HW Chan, WP Rowe, and MA Martin

A series of recombinant plasmids containing polyoma virus (PY) DNA were constructed, and their biological activity was evaluated in mice and in cultured mouse cells. While all of the recombinants studied contain the complete, potentially infectious viral DNA, in no case was the intact recombinant PY-plasmid DNA, or live Escherichia coli containing the recombinant plasmids, capable of inducing PY infection of mice, either by feeding or by parenteral injection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Safety concerns and genetic engineering in agriculture.
W. Brill (1985)
Science 227, 381-384
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Isolation of mutants of an animal virus in bacteria.
K. Peden, J. Pipas, S Pearson-White, and D Nathans (1980)
Science 209, 1392-1396
   Abstract »    PDF »
Tumorigenicity of Polyoma Virus in Hamsters.
M. A. Israel, K. Chowdhury, J. Ramseur, K. Chandrasekaran, D. F. Vanderryn, and M. A. Martin (1980)
Cold Spring Harb Symp Quant Biol 44, 591-596
   Abstract »    PDF »
Molecular cloning of polyoma virus DNA in Escherichia coli: oncogenicity testing in hamsters.
M. Israel, H. Chan, M. Martin, and W. Rowe (1979)
Science 205, 1140-1142
   Abstract »    PDF »
Molecular cloning of polyoma virus DNA in Escherichia coli: lambda phage vector system.
H. Chan, M. Israel, C. Garon, W. Rowe, and M. Martin (1979)
Science 203, 887-892
   Abstract »    PDF »


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