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Science 2 March 1979:
Vol. 203. no. 4383, pp. 841 - 849
DOI: 10.1126/science.419408
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Articles

Science, Vol 203, Issue 4383, 841-849
Copyright © 1979 by American Association for the Advancement of Science

articles

Timers in developing systems

DR Soll

Conditional methods are proposed for investigating the number and relationships of processes that are rate-limiting for the genesis of consecutive stages in a developmental sequence. These methods depend on the differential sensitivity of "timer" pathways to small changes in temperature and can be applied to any developmental sequence in which discrete stages can be reproducibly monitored with time. We have applied the methods to multicellular morphogenesis in the slime mold Dictyostelium discoideum and have obtained an unexpected tentative scheme for timer relationships. A minimum of six timers has been delineated, each specific for at least one morphological stage. The majority of these timers appear to be in parallel.


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The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis.
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Computer-assisted analysis of filopod formation and the role of myosin II heavy chain phosphorylation in Dictyostelium.
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Intracellular Role of Adenylyl Cyclase in Regulation of Lateral Pseudopod Formation during Dictyostelium Chemotaxis.
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The role of myosin heavy chain phosphorylation in Dictyostelium motility, chemotaxis and F-actin localization.
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J. Cell Sci. 117, 4819-4835
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RasC Plays a Role in Transduction of Temporal Gradient Information in the Cyclic-AMP Wave of Dictyostelium discoideum.
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Eukaryot. Cell 3, 646-662
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Shared, unique and redundant functions of three members of the class I myosins (MyoA, MyoB and MyoF) in motility and chemotaxis in Dictyostelium.
D. L. Falk, D. Wessels, L. Jenkins, T. Pham, S. Kuhl, M. A. Titus, and D. R. Soll (2003)
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Constitutively Active Protein Kinase A Disrupts Motility and Chemotaxis in Dictyostelium discoideum.
H. Zhang, P. J. Heid, D. Wessels, K. J. Daniels, T. Pham, W. F. Loomis, and D. R. Soll (2003)
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Phosphorylation of the myosin regulatory light chain plays a role in motility and polarity during Dictyostelium chemotaxis.
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The Internal Phosphodiesterase RegA Is Essential for the Suppression of Lateral Pseudopods during Dictyostelium Chemotaxis.
D. J. Wessels, H. Zhang, J. Reynolds, K. Daniels, P. Heid, S. Lu, A. Kuspa, G. Shaulsky, W. F. Loomis, and D. R. Soll (2000)
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Clathrin plays a novel role in the regulation of cell polarity, pseudopod formation, uropod stability and motility in Dictyostelium.
D Wessels, J Reynolds, O Johnson, E Voss, R Burns, K Daniels, E Garrard, T. O'Halloran, and D. Soll (2000)
J. Cell Sci. 113, 21-36
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